Author/Authors :
Abdi, Fatemeh Student Research Committee - Nursing and Midwifery Faculty - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Mobedi, Hamid Biomaterials Department - Iran Polymer and Petrochemical Institute, Tehran, Iran , Bayat, Farhad Research and Production Complex, Tehran, Iran , Mosaffa, Nariman Department of Immunology - Faculty of medicine - ShahidBeheshti University of Medical Sciences, Tehran, Iran , Dolatian, Mahrokh Department of Reproductive Health - Nursing and Midwifery Faculty - ShahidBeheshti University of Medical Sciences, Tehran, Iran , Ramezani Tehrani, Fahimeh Reproductive Endocrinology Research Center - Research Institute for Endocrine Sciences - ShahidBeheshti University of Medical Sciences, Tehran, Iran
Abstract :
Due to its minimal systematic adverse effects, transdermal estrogen is widely used for the
prevention of osteoporosis in postmenopausal women. The present meta-analysis aimed to
clarify the effects of transdermal estrogen on bone mineral density (BMD) of postmenopausal
women. Studies were identified by searching electronic databases including Cochrane Library,
MEDLINE, Embase , and CINAHL databases, and also the Sciences Citation Index. Systematic
review of articles was published between January 1989 to February 2016.Reference lists of the
included articles were also evaluated and consultations were made with relevant experts. While
132 studies included the desired keywords, only nine clinical trials met the inclusion criteria and
were finally reviewed. The pooled percent change in BMD was statistically significant in favor
of transdermal estrogen. According to resulting pooled estimate, lumbar spine BMD one and
two years after transdermal estrogen therapy was respectively 3.4% (95% CI: 1.7-5.1) and 3.7%
(95% CI: 1.7-5.7) higher than the baseline values. The test for heterogeneity was not statistically
significant based on the I2 heterogeneity index. One-two years of transdermal estrogen delivery
can effectively increase BMD and protect the bone structure in postmenopausal women.
