Title of article :
Anti-Viral Evaluation of Sesquiterpene Coumarins from Ferula assa-foetida against HSV-1
Author/Authors :
Ghannadi, Alireza Isfahan Pharmaceutical Sciences Research Center - school of Pharmacy and Pharmaceutical Sciences - Isfahan University of Medical Sciences , Fattahian, Khadijeh Isfahan Pharmaceutical Sciences Research Center - school of Pharmacy and Pharmaceutical Sciences - Isfahan University of Medical Sciences , Shokoohinia, Yalda Novel Drug Delivery Research Center & Department of Pharmacognosy and Biotechnolog - School of Pharmacy - Kermanshah University of Medical Sciences , Behbahani, Mandana Department of Biotechnology - Faculty of Advanced Sciences and Technologies - University of Isfahan, Isfahan , Shahnoush, Alireza Department of Chemistry - University of Isfahan
Abstract :
Several complications attributed with Herpes virus related infections and the emergence of drug resistant viruses prompt scientists to search for new drugs. Several terpenoids and coumarins have shown anti HSV effects while no sesquiterpene coumarins have been previously tested for HSV treatment. Three sesquiterpene coumarins badrakemin acetate (1), kellerin (2) and samarcandin diastereomer (3) were isolated from the gum resin of Ferula assafoetida, a herbal medicine with antimicrobial, antiprotozoal and antiviral effects. Compounds were identified by 1D and 2D- NMR spectroscopies and comparison with literature data. A comparative evaluation of cytotoxicity and antiviral activity showed that kellerin (2) could
significantly inhibit the cytopathic effects and reduce the viral titre of the herpes virus type 1 (HSV-1) DNA viral strain KOS at concentrations of 10, 5 and 2.5 μg/mL.
Keywords :
Kellerin , Badrakemin acetate , Samarcandin diastereomer , Ferula assa-foetida , Herpes simplex
Journal title :
Astroparticle Physics
