Author/Authors :
Delavari, Alireza Digestive Oncology Research Center - Digestive Disease Research Institute - Shariati Hospital - Tehran University of Medical Sciences , Salimzadeh, Hamideh Digestive Oncology Research Center - Digestive Disease Research Institute - Shariati Hospital - Tehran University of Medical Sciences , Bishehsari, Faraz Department of Internal Medicine - Division of Gastroenterology - Rush University Medical Center , Sobh Rakhshankhah, Elham Digestive Oncology Research Center - Digestive Disease Research Institute - Shariati Hospital - Tehran University of Medical Sciences , Delavari, Farnaz Non-Communicable Disease Research Center - Tehran University of Medical Sciences , Moossavi, Shirin Digestive Oncology Research Center - Digestive Disease Research Institute - Shariati Hospital - Tehran University of Medical Sciences , Khosravi, Pejman Digestive Oncology Research Center - Digestive Disease Research Institute - Shariati Hospital - Tehran University of Medical Sciences , Nasseri-Moghaddam, Siavosh Digestive Oncology Research Center - Digestive Disease Research Institute - Shariati Hospital - Tehran University of Medical Sciences , Merat, Shahin Digestive Oncology Research Center - Digestive Disease Research Institute - Shariati Hospital - Tehran University of Medical Sciences , Ansari, Reza Digestive Oncology Research Center - Digestive Disease Research Institute - Shariati Hospital - Tehran University of Medical Sciences , Vahedi, Homayoon Digestive Oncology Research Center - Digestive Disease Research Institute - Shariati Hospital - Tehran University of Medical Sciences , Shahbazkhani, Bijan Digestive Oncology Research Center - Digestive Disease Research Institute - Shariati Hospital - Tehran University of Medical Sciences , Saberifiroozi, Mehdi Digestive Oncology Research Center - Digestive Disease Research Institute - Shariati Hospital - Tehran University of Medical Sciences , Sotoudeh, Masoud Digestive Oncology Research Center - Digestive Disease Research Institute - Shariati Hospital - Tehran University of Medical Sciences , Malekzadeh, Reza Digestive Oncology Research Center - Digestive Disease Research Institute - Shariati Hospital - Tehran University of Medical Sciences
Abstract :
BACKGROUND
The incidence of colorectal cancer is rising in several developing countries.
In the absence of integrated endoscopy and pathology databases, adenoma detection
rate (ADR), as a validated quality indicator of screening colonoscopy,
is generally difficult to obtain in practice. We aimed to measure the correlation
of polyp-related indicators with ADR in order to identify the most accurate
surrogate(s) of ADR in routine practice.
METHODS
We retrospectively reviewed the endoscopic and histopathological findings
of patients who underwent colonoscopy at a tertiary gastrointestinal clinic. The
overall ADR and advanced-ADR were calculated using patient-level data. The
Pearson’s correlation coefficient (r) was applied to measure the strength of the
correlation between the quality metrics obtained by endoscopists.
RESULTS
A total of 713 asymptomatic adults aged 50 and older who underwent their
first-time screening colonoscopy were included in this study. The ADR and
advanced-ADR were 33.00% (95% CI: 29.52-36.54) and 13.18% (95% CI:
10.79-15.90), respectively. We observed good correlations between polyp
detection rate (PDR) and ADR (r=0.93), and mean number of polyp per patient
(MPP) and ADR (r=0.88) throughout the colon. There was a positive,
yet insignificant correlation between advanced ADRs and non-advanced ADRs
(r=0.42, p=0.35).
CONCLUSION
MPP is strongly correlated with ADR, and can be considered as a reliable
and readily obtainable proxy for ADR in opportunistic screening colonoscopy
programs.
Keywords :
ADR , MPP , Colon cancers , Colonic polyps , Screening colonoscopy
