Author/Authors :
Fotsing Ngamgwe, Rosine Department of Organic Chemistry - Faculty of Science - TWAS Research Unit - University of Yaoundé 1, P. O. Box 812 - Yaoundé, Cameroon , Yankam, Raoul Department of Clinical Research - University of Bern - Murtenstrasse 35, CH-3010 Bern, Switzerland , Rodolphe Chouna, Jean Department of Chemistry - Faculty of Science - University of Dschang, P. O. Box 67, Dschang, Cameroon , Lanz, Christian Department of Clinical Research - University of Bern - Murtenstrasse 35, CH-3010 Bern, Switzerland , Furrer, Julien Department of Chemistry and Biochemistry - University of Bern - Freiestrasse 3, CH-3012 Berne, Switzerland , Schürch, Stefan Department of Chemistry and Biochemistry - University of Bern - Freiestrasse 3, CH-3012 Berne, Switzerland , Kaiser, Marcel Swiss Tropical and Public Health Institute, Socinstrasse 57, CH-4002 Basel, Switzerland - University of Basel - Petersplatz 1, CH-4003 Basel, Switzerland , Ndjakou Lenta, Bruno Department of Chemistry - Higher Teacher Training College - University of Yaoundé 1, P. O. Box 47, Yaoundé, Cameroon , Ngouela, Silvère Department of Clinical Research - University of Bern - Murtenstrasse 35, CH-3010 Bern, Switzerland , Tsamo, Etienne Department of Organic Chemistry - Faculty of Science - TWAS Research Unit - University of Yaoundé 1, P. O. Box 812 - Yaoundé, Cameroon , Brenneisen, Rudolf Department of Clinical Research - University of Bern - Murtenstrasse 35, CH-3010 Bern, Switzerland
Abstract :
Phytochemical investigation of a dichloromethane-methanol (1:1) extract of the fruit pericarp of Omphalocarpum procerum which exhibited antiplasmodial activity during preliminary screening led to the isolation of the new fatty ester triterpenoid 3β- hexadecanoyloxy-28- hydroxyolean-12-en-11-one (1), together with five known compounds 2-6. The structure of the new compound as well as those of the known compounds was established by means of spectroscopic methods and by comparison with previously reported data. Compounds 1- 4 were evaluated in-vitro for their cytotoxicity against L6 cell lines and antiprotozoal activities against Plasmodium falciparum, Leishmania donovani, Trypanosoma brucei rhodesiense and
Trypanosoma cruzi (species responsible for human malaria, visceral leishmaniasis, African trypanosomiasis and Chagas disease, respectively). The tested compounds showed weak to moderate antiprotozoal activity and, no significant effect was detected regarding their cytotoxic potency.
Keywords :
Sapotaceae , Omphalocarpum procerum , Triterpenoid , Procerenone , Antiparasitic activity
