Author/Authors :
Mohammadi Ziarani, Ghodsi Department of Chemistry - Alzahra University, Tehran, Iran , Aleali, Faezeh Department of Chemistry - Alzahra University, Tehran, Iran , Lashgari, Negar Department of Chemistry - Alzahra University, Tehran, Iran , Badiei, Alireza School of Chemistry - College of Science - University of Tehran, Tehran, Iran , Abolhasani Soorki, Ali ACECR-Research Institute of Applied Sciences - Shahid Beheshti University, Tehran, Iran
Abstract :
A simple, efficient, and environmentally friendly method has been developed for the
synthesis of a series of tricyclic fused pyrazolopyranopyrimidines via a one-pot three-component
reaction of barbituric acids, aromatic aldehydes, and 3-methyl-5-pyrazolone in the presence of
SBA-Pr-SO3H. SBA-15 mesoporous silica material functionalized with propyl sulfonic acid
groups was used as a heterogeneous Brønsted acid catalyst with hexagonal structure, high
surface area, thick walls, and large uniform pores. All reactions were performed under reflux
conditions in water in the presence of a catalytic amount of SBA-Pr-SO3H. High yields, mild
reaction conditions, short reaction times, and simple work-up procedures are some advantages
of this method. The antimicrobial activities of the synthesized compounds were also evaluated
and some products exhibited significant antibacterial activities at low concentrations.
Keywords :
Pyranopyrimidine , Barbituric acid , Antimicrobial activity , Green synthesis , SBA-Pr-SO3H
