Author/Authors :
Zare, Somayeh Medicinal and Natural Products Chemistry Research Center - Shiraz University of Medical Sciences, Shiraz - Department of Phytochemistry - Yasouj University, Yasouj , Ghaedi, Mehrorang Department of Phytochemistry - Yasouj University, Yasouj , Miri, Ramin Medicinal and Natural Products Chemistry Research Center - Shiraz University of Medical Sciences , Heiling, Sven Department of Molecular Ecology - Max Planck Institute for Chemical Ecology - Hans- Knöll-Strasse 8, D-07745 Jena, Germany , Asadollahi, Mojtaba Medicinal and Natural Products Chemistry Research Center - Shiraz University of Medical Sciences , Baldwin, Ian T Department of Molecular Ecology - Max Planck Institute for Chemical Ecology - Hans- Knöll-Strasse 8, D-07745 Jena, Germany , Jassbi, Amir Reza Medicinal and Natural Products Chemistry Research Center - Shiraz University of Medical Sciences
Abstract :
Euphorbia macrostegia or Persian wood spurge is one of the seventeen endemic plants of this genus in Iran. Three triterpenoids, 24-methylenecycloartan-3β-ol (1), butyrospermol (2) and cycloartenol (3) and three diglycerides, 1,2-di-O-α-linolenoyl-sn-glycerol (4), 1-O-linoleoyl-3- O-palmitoyl-sn-glycerol (5) and 1-O-α-linolenoyl-2-O-palmitoyl-sn-glycerol (6) were isolated from the hexane soluble part of methanol-dichloromethane extracts of the aerial parts of Euphorbia macrostegia Boiss. The structures of all compounds were elucidated using different spectroscopy methods including, 1H NMR, 13C NMR, HSQC, HMBC, EI-MS and IR. The triterpenes and the unsaturated fatty acids moieties of the diglycerides isolated from the plant were reported previously to have analgesic, anticancer, bactericidal and antifungal activity.
Here, we show that E. macrostegia is a new source for the above mentioned biologically active compounds.
Keywords :
Euphorbiaceae , Euphorbia macrostegia , Cycloartane triterpenoids , Diglycerides of fatty acids
