Title of article :
Protective Role of Oleuropein against Acute Deltamethrin- Induced Neurotoxicity in Rat Brain
Author/Authors :
Khalatbary, Ali Reza Molecular and Cell Biology Research Center - Dept. of Anatomy - Faculty of Medicine - Mazandaran University of Medical Sciences , Ghaffari, Elmira Dept. of Anatomy - Faculty of Medicine - Mazandaran University of Medical Sciences , Mohammadnegad, Behrooz Dept. of Anatomy - Faculty of Medicine - Mazandaran University of Medical Sciences
Abstract :
Background: Deltamethrin (DM) is a synthetic pyrethroid insecticide that can elicit neurotoxicity, leading to
apoptosis. There is accumulating evidence that oleuropein (OE) has anti-apoptotic effect. The purpose of this study
was to determine the anti-apoptotic effect of OE pretreatment in the neuronal cells of cerebral cortex. Methods:
Rats were randomly divided into four groups each containing five rats: DM-treated group (12.5 mg/kg, a single
dose), OE-treated group (20 mg/kg per day), DM + OE-treated group, and vehicle group. Sections of the brain were
obtained 24 hours after DM injection and studied for histopathological and immunohistochemistry assessment.
Results: The histopathological assessments showed lesser characteristics of neural degeneration in DM + OE group
compared with DM group. Greater Bcl-2 and attenuated Bax expression could be detected in the DM + OE treatedmice
compared with DM group. Conclusion: The results suggested that DM-induced neurotoxicity can be subsided
by OE. Iran. Biomed. J. 19 (4): 247-253, 2015
Keywords :
Apoptosis , Oleuropein , Deltamethrin
Journal title :
Astroparticle Physics
