Author/Authors :
Esfahanizadeh, Marjan Central Research Laboratories - Shahid Beheshti University of Medical Sciences, Tehran - Department of Medicinal Chemistry - School of Pharmacy - Shahid Beheshti University of Medical Sciences, Tehran , Mohebbi, Shohreh Department of Medicinal Chemistry - School of Pharmacy - Zanjan University of Medical Sciences, Zanjan , Dasht Bozorg, Behnam Department of Medicinal Chemistry - School of Pharmacy - Shahid Beheshti University of Medical Sciences, Tehran , Amidi, Salimeh Department of Medicinal Chemistry - School of Pharmacy - Shahid Beheshti University of Medical Sciences, Tehran , Gudarzi, Ali Department of Medicinal Chemistry - School of Pharmacy - Shahid Beheshti University of Medical Sciences, Tehran , Ayatollahi, Abdolmajid Phytochemistry Research Center - Shahid Beheshti University of Medical Sciences, Tehran - Department of Medicinal Chemistry - School of Pharmacy - Shahid Beheshti University of Medical Sciences, Tehran , Kobarfard, Farzad Phytochemistry Research Center - Shahid Beheshti University of Medical Sciences, Tehran - Department of Medicinal Chemistry - School of Pharmacy - Shahid Beheshti University of Medical Sciences, Tehran - Central Research Laboratories -Shahid Beheshti University of Medical Sciences, Tehran
Abstract :
A series of novel 2-aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine derivatives have been synthesized and their antiplatelet aggregation activities were assessed against ADP and arachidonic acid-induced platelet aggregation in human plasma using light transmission aggregometry. Among the tested derivatives, compounds Ia, Ib, IB and II16 exhibited the highest antiplatelet aggregation activity (36.75, 72.4, 62.5 and 80 μM). None of the compounds showed satisfactory activity against the aggregation induced by ADP but acceptable activities were observed against the aggregation induced by arachidonic acid. 2- aminopyrimidines were more
active than 4,6- diaminopyrimidines in this respect.
Keywords :
2-aminopyrimidines , 2-Substituted-4,6-diaminopyrimidines , Antiplatelet aggregation
