Title of article :
Screening of Different Extracts from Artemisia Species for Their Potential Antimalarial Activity
Author/Authors :
Mojarrab, Mahdi Novel Drug Delivery Research Center - School of Pharmacy - Kermanshah University of Medical Sciences, Kermanshah , Naderi, Rozhin Novel Drug Delivery Research Center - School of Pharmacy - Kermanshah University of Medical Sciences, Kermanshah - Student Research Committee - Kermanshah University of Medical Sciences, Kermanshah , Heshmati Afshar, Fariba Drug Applied Research Center - Tabriz University of Medical Sciences
Abstract :
The formation of hemozoin (malaria pigment) has been proposed as an ideal drug target for antimalarial screening programs. In this study, we used an improved, cost-effective and highthroughput spectrophotometric assay to screen plant extracts for finding novel antimalarial plant sources. Fifteen extracts with different polarity from three Iranian Artemisia species, A. ciniformis, A. biennis and A. turanica, were assessed for their antimalarial activity by invitro β-hematin formation assay. The most potent effect was observed in dichloromethane (DCM) extract of A. ciniformis with IC50 and IC90 values of 0.92 ± 0.01 and 1.29 ± 0.02 mg/ mL, respectively. Ethyl acetate (EtOAC) extracts of A. biennis and A. turanica also showed significant antimalarial activities with IC50 values of 1.11 ± 0.02 and 1.35 ± 0.08 mg/mL and IC90 values of 1.22 ± 0.04 and 2.81 ± 0.21 mg/mL, respectively. Based on these results, it is possible to conclude that the components with strong antimalarial activity have been concentrated in the medium-polar extracts.
Keywords :
β-hematin formation , Artemisia ciniformis , Artemisia biennis , Artemisia turanica , Antimalaria
Journal title :
Astroparticle Physics
