The Use of Citric Acid for the Treatment of Chronic Non-Healing Sinus

A discharging sinus not responding to conventional therapy becomes a chronic non- healing sinus. Conventional/traditional therapies have their own limitations in the management of chronic discharging non-healing sinus. Thus, the treatment of such non-healing sinus is a big worry for a clinician. We report a case of non-healing sinus, which did not respond to conventional antimicrobial treatment and local care combined for years, but was treated successfully by using three percent citric acid as a sole topical antimicrobial agent. A 22-year-old unmarried female referred to an orthopedic surgeon with a chronic discharging sinus at the right mid-tarsal region. The case was examined thoroughly. Followings are the details of various examinations: Haemoglobin; 11.6 gm/dl, white blood cell count; 5400/mm3, differential leucocyte count: neutrophils; 61%, lymphocytes; 31%, monocytes; 3%, eosinophils; 4% and basophils; 1%, peripheral blood smear; normocytic, normochromic, mildly hypochromic, and ansiocytosis, Erythrocyte sedimentation rate (ESR); 46 mm/hr, serum uric acid; 4.8 mg/dl; C-reactive protein; absent, rheumatoid arthritis factor (R. A factor); absent, urine analysis; Nothing abnormal detected (NAD), anterior-posterior and oblique X-rays of right foot; osteoporosis of lateral bones with a soft tissue swelling and chronic soft tissue infection, enzyme linked immunosorbent assay test (ELISA) for antimycobacterium tuberculosis antibodies: IgG; 140 units/ml and IgM; 1.0 units/ml, and weight of the patient; 50 kg. The case was diagnosed as Koch’s mid-tarsal joints, based on the laboratory and clinical findings. There was no osteomyelitis. The patient thereafter was subjected to Anti-Koch’s (multidrug) therapy with a four- drug regimen involving rifampicin, pyrazinamide, isoniazid and ethambutol for one year. The patient was considered responsive on the basis of weight gain (55 kg) and decreased ESR level (28 mm/hr). However, the sinus was persistent without any clinical improvement in spite of Anti-Koch’s therapy for one year. This prompted the clinician to start antibiotic therapy. Different groups of antibiotics were tried for two months without any changes in sinus presentation (figure 1A). Finally the patient approached us for citric acid therapy, which she received duly. The sinus was flushed with normal saline and was irrigated with 3 % citric acid. Cotton swabs soaked with citric acid were placed in the sinus opening. This modality of local application of citric acid was carried out for 11 days (one application each day). The sinus showed signs of healing, and was closed completely within two weeks of therapy (figure 1B). Thereafter, the patient was followed up for six months, and no draining from sinus was observed. The effective use of citric acid in the treatment of acute and chronic wounds and ulcers has been reported. Excellent results of citric acid therapy have been obtained while dealing with chronic wounds.1-5 Citric acid physiologically functions as an antibacterial agent and effectively controls the infection as indicated by microbiological studies and by rapid clearing up of infected surfaces.6 The antiseptic property may be due to the lowering of pH of the infected surfaces, which makes the envi-