Author/Authors :
Panahi-Azar, Vahid Liver and Gastrointestinal Diseases Research Center - Tabriz University of Medical Sciences , Soltanpour, Shahla Faculty of Pharmacy - Zanjan University of Medical Sciences, Zanjan , Martinez, Fleming Grupo de Investigaciones Farmacéutico-Fisicoquímicas - Departamento de Farmacia - Universidad Nacional de Colombia - Bogotá D.C., Colombia , Jouyban, Abolghasem Drug Applied Research Center and Faculty of Pharmacy - Tabriz University of Medical Sciences, Tabriz - Pharmaceutical Engineering Laboratory - School of Chemical Engineering - College of Engineering - University of Tehran
Abstract :
The solubility of naproxen in binary mixtures of polyethylene glycol 200 (PEG 200) + water at the temperature range from 298.0 K to 318.0 K were reported. The combinations of Jouyban- Acree model + van’t Hoff and Jouyban-Acree model + partial solubility parameters were used to predict the solubility of naproxen in PEG 200 + water mixtures at different temperatures. Combination of Jouyban-Acree model with van’t Hoff equation can be used to predict solubility in PEG 200 + water with only four solubility data in mono-solvents. The obtained solubility calculation errors vary from ~ 17 % up to 35 % depend on the number of required input data. Non-linear enthalpy-entropy compensation was found for naproxen in the investigated solvent system and the Jouyban−Acree model provides reasonably accurate mathematical descriptions
of the thermodynamic data of naproxen in the investigated binary solvent systems.
Keywords :
Thermodynamic analysis , Solubility , Naproxen , Jouyban–acree model
