Author/Authors :
Yıldırım, Şule Department of Pediatrics - Faculty of Medicine - Çanakkale Onsekiz Mart University, Çanakkale, Turkey , Topaloglu, Naci Department of Pediatrics - Faculty of Medicine - Çanakkale Onsekiz Mart University, Çanakkale, Turkey , Tekin, Mustafa Department of Pediatrics - Faculty of Medicine - Canakkale Onsekiz Mart University, Canakkale, Turkey , Kucuk, Adem Department of Pediatric Surgery - Düzce Atatürk State Hospital, Düzce, Turkey , Erdem, Havva Department of Pathology - Düzce University Medical Faculty, Düzce, Turkey , Erbas, Mesut Department of Anesthesiology - Faculty of Medicine - Canakkale Onsekiz Mart University , Yıldırım, Ahmet Department of Emergency Medicine - Faculty of Medicine - Canakkale Onsekiz Mart University, Çanakkale, Turkey
Abstract :
Background: Proanthocyanidin is a potent bioactive antioxidant naturally occurring in grape seed
and acts as reactive oxygen species (ROS) scavenger. The aim of this study was to investigate the
effects of proanthocyanidinin in experimental ovarian torsion injury.
Methods: Twenty four rats were randomly divided into three groups (n=8). Group 1: the laparotomy
group, group 2: ovarian torsion group, and group 3: intervention group administered proanthocyanidinin
of 50 mg/kg before bilateral ovarian ischemia and reperfusion. Histologic examination and
scoring was done at the end of the experiment. Statistical analyses were performed using the SPSS v.
19.
Results: Ovarian histopathologic findings of all three groups were significantly different in terms of
hemorrhage (p<0.001), edema (p=0.001) and vascular dilatation (p< 0.001). Pathologic changes induced
by I/R were reduced in ovaries of rats administered proanthocyanidin, in particular, hemorrhage,
edema and vascular dilatation.
Conclusion: Proanthocyanidin, known as free radical scavenger and antioxidant, is protective
against tissue damage induced by ischemia and/or ischemia/reperfusion in rat ovaries.
Keywords :
Ovarian torsion , Ischemia Reperfusion , Fertility , Proanthocyanidinin
