Author/Authors :
Amirpour, Mojgan Mashhad University of Medical Sciences, Mashhad, Iran , Ayatollahi, Hossein Cancer Molecular Pathology Research Center - Department of Hematology and Blood Bank - Faculty of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran , Sheikhi, Maryam Cancer Molecular Pathology Research Center - Department of Hematology and Blood Bank - Mashhad University of Medical Sciences, Mashhad, Iran , Azarkerdar, Somaye Mashhad University of Medical Sciences, Mashhad, Iran , Shams, Fatemeh Cancer Molecular Pathology Research Center - Department of Hematology and Blood Bank - Mashhad University of Medical Sciences, Mashhad, Iran
Abstract :
Background: Acute myeloid leukemia (AML) is known as one of the most common leukemia among adults.
Environmental and different genetic factors affect disease process, prognosis and treatment. Among different
genetic factors NPM1, FLT3, MLL and BAALC genes are the most effective on patient's survival rate. The aim
of this study was to assess amount of BAALC gene expression in AML patients, and its relation to survival rate.
Methods: In this case-control study, from all 94 individuals referred to Ghaem Medical Center during 2012-
2015, 47 cases were normal cytogenetic AML and others were healthy individuals that were studied as control
group. Real-time PCR method was applied for gene expression evaluation. Other information of patients was
extracted from medical documents. SPSS v.21 was used for data processing.
Results: Mean age of studied cases was 31.50 years. The most of BAALC gene expression was seen in M1
and M2 subtypes, and the less was in M5. A significant relation was found between amount of gene expression
and patient's survival rate.
Conclusion: BAALC gene expression was increased significantly in AML cases. BAALC expression had reverse
relation with patients' survival rate in North-East of Iran.
