Author/Authors :
Amirazodi, Esmael Shiraz Institute for Cancer Research - School of Medicine - Shiraz University of Medical Sciences, Shiraz , Razmkhah, Mahboobeh Shiraz Institute for Cancer Research - School of Medicine - Shiraz University of Medical Sciences, Shiraz , Jaberipour, Mansoureh Shiraz Institute for Cancer Research - School of Medicine - Shiraz University of Medical Sciences, Shiraz , Hosseini, Ahmad Shiraz Institute for Cancer Research - School of Medicine - Shiraz University of Medical Sciences, Shiraz , Khademi, Bijan Department of ENT - School of Medicine - Shiraz University of Medical Sciences, Shiraz
Abstract :
Background: Interleukin (IL)-4 is a member of T helper 2 (Th2) axis produced by T-lymphocytes and mast cells. It has been shown that IL-4 expression changes in tumor tissues. The main objective of this study is to investigate the expression of IL-4 mRNA in patients with Laryngeal Squamous Cell Carcinoma (LSCC) with or without lymph node involvement. Materials and Methods: mRNA expression of IL-4 in LSCC tissues were detected by quantative Real-Time PCR (qRT-PCR). Expression of IL-4 gene was compared between lymph node positive and negative patients with Squamous Cell Carcinoma of Larynx. Results: No statistically significant association was found in expression of IL-4 between lymph node positive and negative patients. Conclusion: It seems that IL-4 has no important effect on the involvement of lymph node in LSCC. However, to achieve a definite conclusion more investigations are certainly required.
Keywords :
Cancer , Interleukin-4 , Lymph Node Metastasis , Larynx , T helper 2
