Author/Authors :
Vafa, Mohammadreza Department of Nutrition - School of Public Health - Iran University of Medical Sciences, Tehran, Iran , Soltani, Sepideh Department of Community Nutrition - School of Nutrition Sciences and Dietetics - Tehran University of Medical Sciences, Tehran, Iran , Zayeri, Farid Departments of Biostatistics - Faculty of Paramedical Sciences - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Niroomand, Mahtab Obesity Research Center - Research Institute for Endocrine Sciences - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Najarzadeh, Azadeh Department of Nutrition - School of Public Health - Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract :
Background: The results of the studies on the effects of sodium on bone metabolism have been inconsistent.
There is no definitive answer to the question of whether sodium restriction can be associated with a lower incidence
of osteoporosis. What reinforces the necessity of designing this study is the lack of findings with the approach
of examining the effects of sodium on bone in our country.
Methods: This was a cross-sectional study conducted on 185 retired female teachers aged 45 to 70. Sodium
intake was evaluated using two methods: A 24-hour recall and a 12-hour urine sample. To assess bone health,
ORAI index was calculated for each individual. Urinary calcium, phosphorus, potassium and serum vitamin D
and PTH were measured as laboratory variables. To compare the general characteristics of the participants
across tertiles of urinary sodium, the analysis of variance (ANOVA) was used for quantitative variables and the
Chi-square test for categorical variables.
Results: Phosphorous, calcium and potassium urinary excretion rate increased with the increase in urinary sodium
(p<0.05). However, the changes in serum vitamin D, and PTH levels across tertiles of urinary sodium
were not significant. Changes in urinary sodium levels were not significant (p=0.933) in ORAI groups (sorted
by rating). The relationship between urinary calcium and sodium was apparent in low calcium intake (r=0.415,
p<0.001), but not in higher calcium intake (r=0.144, p=0.177).
Conclusion: Although urinary calcium and potassium increased with the increase in sodium intake, no relationship
was found between sodium and ORAI.
Keywords :
Bone Health , ORAI , Urinary Calcium , Urinary Sodium