Effect of Proton Pump Inhibitor Based Triple Therapy with Apple Cider Vinegar on Helicobacter Pylori Eradication

Background: The purpose of this study was to evaluate the effect of apple cider vinegar plus PPI-based triple therapy on eradication of Helicobacter Pylori (H.pylori) infection. Materials and Methods: 116 patients with H. pylori infection were included in this randomized clinical trial. Patients in control group (n=59) received amoxicillin, clarithromycin, and pantaprazole twice daily. Patients in study group (57 patients) received the same regimen plus 30 mL of apple cider vinegar twice daily. The duration of therapy for study and control were 10 and 14 days respectively. Four weeks after the completion of therapy, Urea breath test was performed to assess the success of H.pylori infection eradication. Results: 86% of patients in control group in comparison to 88% in apple cider vinegar group responded to eradication therapy (P=0.41). Conclusion: Addition of apple cider vinegar to proton pomp inhibitor (PPI)-based triple therapy may decrease the duration of H. pylori treatment but it was not statistically significant. Thus, our results showed no efficacy of apple cider vinegar in H. pylory eradication treatment.