Author/Authors :
Jamshidi, Javad Noncommunicable Diseases Research Center - Fasa University of Medical Sciences, Fasa, Iran , Asnaashari, Ali Student Research Committee - Fasa University of Medical Sciences, Fasa, Iran , Alipoor, Reza Department of Biochemistry - Hormozgan University of Medical Sciences, Bandar Abbas, Iran , Mohammadi, Sina Student Research Committee - Fasa University of Medical Sciences, Fasa, Iran , Roostaei, Sara Student Research Committee - Fasa University of Medical Sciences, Fasa, Iran , Samadian, Mohammad Mahdi Department of Medical Genetics - Mashhad University of Medical Sciences, Mashhad, Iran , Honarmand Aliabadi, Saiedeh Student Research Committee - Fasa University of Medical Sciences, Fasa, Iran , Bahramali, Ehsan Noncommunicable Diseases Research Center - Fasa University of Medical Sciences, Fasa, Iran
Abstract :
Background: ATP2B1 and STK39 have been introduced as essential hypertension candidate genes. The association of these genes’
variations have not been studied in Iranian population yet. Here we aimed to investigate the association of ATP2B1 rs2681472 and
STK39 rs35929607 polymorphisms with the risk of hypertension in an Iranian population.
Methods: We included 400 individuals in our case-control study: 200 cases with essential hypertension and 200 healthy sex and age
matched controls. All subjects were genotyped for rs2681472 and rs35929607 using a PCR-RFLP method. Genotype and allele frequencies
were compared between the two groups using chi-squared test. The association was further assessed under log-additive, dominant
and recessive genetic models.
Results: There was no association between rs2681472 and rs35929607 polymorphisms and risk of essential hypertension in our
population (p>0.05). There was also no association between the studied polymorphisms and hypertension under different genetic models.
Conclusion: Our study indicated that rs2681472 of ATP2B1 and rs35929607 of STK39 may not have a significant effect on the risk
of essential hypertension in Iranian population. More studies are still needed to validate our results.
Keywords :
Association study , Polymorphism , STK39 , ATP2B1 , Essential hypertension
