Author/Authors :
Heydari, Iraj Endocrine Research Center - Institute of Endocrinology and Metabolism - Iran University of Medical Sciences, Tehran, Iran , Honardoost, Maryam Endocrine Research Center - Institute of Endocrinology and Metabolism - Iran University of Medical Sciences, Tehran, Iran , Moradi, Sedighe Endocrine Research Center - Institute of Endocrinology and Metabolism - Iran University of Medical Sciences, Tehran, Iran , Golgiri, Fatemeh Endocrine Research Center - Institute of Endocrinology and Metabolism - Iran University of Medical Sciences, Tehran, Iran , Dehnad, Hamidreza Endocrine Research Center - Institute of Endocrinology and Metabolism - Iran University of Medical Sciences, Tehran, Iran , Moradi, Saba Shahid Beheshti University of Medical Sciences, Tehran, Iran , Ziaee, Amir Pediatric Growth and Development Research Center - Institute of Endocrinology and Metabolism , Iran University of Medical Sciences Tehran, Iran
Abstract :
Background: Multinodular goiter (MNG) is regarded as one of the most common causes of hyperthyroidism, particularly in areas of
mild-to-moderate iodine deficiency. The present study aims to explore the effects of the radioactive iodine (RAI) therapy on benign
non-toxic MNG and evaluate its side effects.
Methods: Patients with benign non-toxic MNG entered the study. Ultrasonography was applied to calculate the percentage of the
decrease in the size of the thyroid before and six months minimum after the treatment. Chi-square, Mann-Whiteny-U and T-test were
done using SPSS v.18.0 (p<0.05).
Results: The volumes of the thyroid lobes and nodules decreased significantly due to RAI therapy (p<0.001). The total volume of
the thyroid, volume of the right nodule, and volume of the left nodule decreased by 77.8%, 40.7%, and 34.6% respectively.
Conclusion: According to the results of the current study, RAI therapy is an effective treatment method although it has short-term
side effects. This treatment option is recommended for patients with benign non-toxic MNG, notably those who cannot be a candidate
for surgery. This treatment affects the size of the thyroid and its nodules significantly and decreases almost all of the complications.
Keywords :
Thyroid , Radioactive iodine therapy , Nodule , Multinodular goiter
