Neuroprotective effects of propolis and caffeic acid phenethyl ester (CAPE) on the radiation-injured brain tissue (Neuroprotective effects of propolis and CAPE)

Background: Our purpose was to invesgate propolis and its component caffeic acid phenethyl ester (CAPE) for their anoxidant effects on the brain ssue of rats exposed to ionizing radiaon (IR). Materials and Methods: Fi&y-four male albino Sprague-Dawley rats, divided into six groups, were designed as normal control group, cranial irradiaon of 5 Gray alone, irradiaon plus CAPE, irradiaon plus propolis, control groups of propolis and CAPE. Oxidave/anoxidave status indicators, lipid peroxidaon and anoxidant enzymes, were determined by biochemical methods in homogenized brain ssue of rats. Results: Malondialdehyde level, the lipid peroxidaon index, in the irradiaon alone group was found to be significantly increased compared to all of the other groups (p<0.001). Enzyme acvies of superoxide dismutase (SOD) were 504.93, 720.70 and 659.98 for irradiaon alone group, irradiaon plus CAPE group and irradiaon plus propolis group, respecvely. Enzyme acvity of SOD in the irradiaon alone group was found to be significantly decreased compared to the groups received propolis or CAPE (p<0.003). Enzyme acvity of glutathione peroxidase was not found stascally different among all of the groups. Conclusion: Propolis and CAPE were found to be beneficial agents in protecng brain ssue against IR-induced oxidave damage.