Potentiometric Detection of Clobutinol Hydrochloride Level using PVC Membrane Sensor and Relative Electronic Circuit

A potentiometric inexpensive sensor has been designed for detection of Clobutinol Hydrochloride level, which is used for curing non-productive coughs. The sensor is capable of doing direct detection of the drug level in the chemical solution using PVC ion-exchange membranes. The ion pair used as the sensing element was made through the interaction of Clobutinol Hydrochloride and Sodium Tetra-Phenyl borate. It is shown that the highest ion-selective electrodes in sensitivity were achieved by 10% ion pair, 45.5% dioctyl phthalateand 44.5% of PVC composition. The sensor response time is found to be less than 10 seconds, with a minimum detectable range of 4.0×10-6M in 0.5×10-1M−1.0×10-5 M range. For measurements, a sensing board in direct and permanent contact with the electrodes is used. This integrated measurement system is made of an ATMEGA16L micro-controller sampling, analyzing and data storage section which makes measurements easier and faster. It also helps with reducing the side effects caused by a traditional multimeter usage such as connection cables resistance.