Title of article :
Up Growth Effect of Cetyltrimethyl Ammonium Bromide with Carbon Paste Electrode for the Electrochemical Determination of Allopurinol and Its Biological Activities
Author/Authors :
Teradale, Amit B Department of Chemistry - BLDEA’s College of Engineering and Technology - Vijayapur - affiliated to Visvesvaraya Technological University , Lamani, Shekappa D Department of Chemistry - BLDEA’s S.B. Arts and K.C.P. Science College , Das, Swastika N Department of Chemistry - BLDEA’s College of Engineering and Technology - Vijayapur - affiliated to Visvesvaraya Technological University
Abstract :
A stable sensor for the determination of allopurinol (AP) was upgrade by effect of surfactant cetyltrimethyl ammonium bromide (CTAB) with running phosphate buffer solution (pH=3.0) at a carbon paste electrode (CPE). A sensitive electrochemical method was improved distinctly in the presence of low concentration of CTAB, the oxidation peak current signifying that CTAB exhibits noticeable enhancement effect to the determination of AP as well as under optimal conditions the linear sweep voltammetry response to AP has a linear concentration over the range from 0.6 μM to 60.0 μM, with limit of detection and quantification 97.2 nM and 0.324 μM respectively. This constructed voltammetry sensor was successfully applied to determination of AP in the human serum sample, urine sample and tablet. Finally this was shown to be sensitive and efficient.
Keywords :
Allopurinol , Surfactant effect , Electrochemical detection , Drug monitoring , Carbon paste electrode
Journal title :
Astroparticle Physics
