Determination of Terazosin by using Poly (Congo red) Modified Carbon Paste Electrode

A simple, sensitive and selective electrochemical method is developed for the determination of terazosin (TR) by using cyclic voltammetry and differential pulse voltammetry. A poly congo red carbon paste electrode (poly CR/CPE) based sensor was successfully fabricated by the electro polymerization process by using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). This modified carbon paste electrode exhibited a good electro catalytic activity towards the resolution of terazosin in 0.1M phosphate buffer solution (PBS) at pH 7.0. The effect of pH, scan rate, concentration of Terazosin were studied by using congo red modified CPE. The modified electrode showed a good detection limit of 7.3 μM over the linear dynamic range of 1.76×10-5M to 3.33×10-5 M, which is better than many reported methods in the literature. The prepared poly (CR) modified electrode exhibited good stability, high sensitivity, better reproducibility, low detection limit towards the determination of Terazosin(TR). Finally, the electrochemical oxidation of TR at the surface of poly CR/ CPE was employed for the determination of TR in real sample analysis.