Title of article :
Electrochemical Oxidation of Masalazine Drug at Poly(glutamic acid) Modified Glassy Carbon Electrode
Author/Authors :
Kumar, Avani Anil Department of Chemistry - Dravidian University , Rani, Tenkela Shobha Department of Chemistry - Dravidian University , Ganesh, Pattan Siddappa Department of PG Studies and Research in Industrial Chemistry - Kuvempu University , Kumara Swamy, Bahaddurghatta Eshwaraswamy Department of PG Studies and Research in Industrial Chemistry - Kuvempu University
Abstract :
A sensitive and quick responsive analytical method was developed for the electrochemical oxidation of masalazine (MSZ) using poly (glutamic acid) modified glassy carbon electrode (MGCE). The modified electrode shows electrocatalytic activity towards the oxidation of MSZ drug in 0.2 M phosphate buffer solution (PBS) of pH 7.4 by cyclic voltammetric (CV) technique. The limit of detection was calculated to be 23.94 nM at modified electrode. The effect of scan rate study reveals an adsorption controlled electrode phenomenon. The modified electrode can be used as an analytical tool for the determination MSZ in pharmaceutical formulations.
Keywords :
Masalazine , Modified glassy carbon electrode , Cyclic voltammetry , Electrocatalytic activity
Journal title :
Astroparticle Physics
