Author/Authors :
ZHANG, Jie Key Laboratory of Biomedical Engineering & Technology of Shandong High School - Shandong Wanjie Medical College, Zibo, China , SUN, Ruijie Dept. of Medicine - Shandong Wanjie Medical Colleg, Zibo, China , LIU, Yue Key Laboratory of Biomedical Engineering & Technology of Shandong High School - Shandong Wanjie Medical College, Zibo, China , WANG, Guinian Dept. of Laboratory Medicine - the First Hospital of Zibo City, Zibo, China
Abstract :
Metallothionein (MT) manifests varying expression levels in carcinomas, and they may be considered as valuable cell cancerization biomarkers for diagnosis of patients with cancers. A meta-analysis was conducted to evaluate compre-hensively the MT expression difference in various benign tumors and malignant tumors, which compared the high with low MT expression levels in patients of the available studies. Finally, a total of 13 studies dealing with various tumors were involved for this meta-analysis. The results indicated that lower expression of MT in various benign tu-mors tissue than that in corresponding malignant tumors with the pooled or of 0.52 (95 % CI 0.18-1.47, P ＜0.001). In conclusion, MT expression difference is associated with tumor various stages in tumor patients and could be a use-ful clinical criteria of distinguishing benign tumors and malignant tumors for those patients
Keywords :
Metallothionein , Benign tumors , Malignant tumors , Meta analysis
