Author/Authors :
Al-Zahrani, Yahya A Department of Medical Pharmacology, College of Medicine - King Abdulaziz University, Jeddah, Saudi Arabia , Al-Harthi, Sameer E Department of Medical Pharmacology, College of Medicine - King Abdulaziz University, Jeddah, Saudi Arabia, Princess Al Jawhara Albrahim Center of Excellence in Research of Hereditary Disorders, Jeddah, Saudi Arabia , Khan, Lateef M Department of Medical Pharmacology, College of Medicine - King Abdulaziz University, Jeddah, Saudi Arabia , El-Bassossy, Hani M Department of Pharmacology and Toxicology, College of Pharmacy - King Abdulaziz University, Jeddah, Saudi Arabia , Edris, Sherif M Princess Al Jawhara Albrahim Center of Excellence in Research of Hereditary Disorders, Jeddah, Saudi Arabia, Department of Biological Sciences - King Abdulaziz University, Jeddah, Saudi Arabia , Alim A. Sattar, Mai A Department of Medical Pharmacology, College of Medicine - King Abdulaziz University, Jeddah, Saudi Arabia, Faculty of medicine - Ain Shams University, Cairo, Egypt
Abstract :
The anti-anginal effects of allopurinol were assessed in experimental model rats of angina and their effects were evaluated with amlodipine. In the vasopressin-induced angina model, oral administration of allopurinol in dose of 10 mg/kg revealed remarkably analogous effects in comparison with amlodipine such as dose-dependent suppression of vasopressin-triggered time, duration and severity of ST depression. In addition, allopurinol produced dose dependent suppression of plasma Malondialdehyde (MDA) level, systolic blood pressure, cardiac contractility and cardiac oxygen consumption; while in contrast, amlodipine minimally suppressed the elevation of plasma MDA level. Endothelial NO synthase (eNOS) expression, serum nitrate were strikingly increased, however lipid profile was significantly reduced. Seemingly, allopurinol was found to be more potent than amlodipine – a calcium channel antagonist. To conclude, it was explicitly observed and verified
that on the ischemic electrocardiography (ECG) changes in angina pectoris model in rats, allopurinol exerts a significant protective effects, reminiscent of enhancement of vascular oxidative stress, function of endothelial cells, improved coronary blood flow in addition to the potential enhancement in myocardial stress. Moreover, our findings were in conformity with several human studies.
Keywords :
Angina pectoris , Vasopressin , Allopurinol , ECG , eNOS expression
