Author/Authors :
Pan, Xin-mei School of Pharmacy - Chongqing Medical University, Chongqing 400016, PR China , Li, Jie School of Pharmacy - Chongqing Medical University, Chongqing 400016, PR China , Gan, Run School of Pharmacy - Chongqing Medical University, Chongqing 400016, PR China , Hu, Xiang-nan School of Pharmacy - Chongqing Medical University, Chongqing 400016, PR China
Abstract :
The aim of this study was to prepare the rosiglitazone sodium enteric-coated tablets and investigate its release rate. The rosiglitazone sodium enteric-coated tablet was prepared by single punch tablet press using substituted hydroxypropyl cellulose and polyvinylpyrrolidone (PVP). The release rate from the enteric-coated tablet of rosiglitazone sodium was evaluated. The release rate study showed that few rosiglitazone sodium was released from enteric coated formulation
within 2 h in simulated gastric juice, while it released more than 80% of the labeled amount in 30 min in simulated intestinal juice. The preparing method of rosiglitazone sodium enteric-coated tablets was simple and had a good reproducibility. The release condition and determined methods could be used for the routine determinations of rosiglitazone sodium enteric-coated tablets.
Keywords :
Enteric-coated tablet , Release tests , Polyvinylpyrrolidone (PVP) , Hydroxypropyl cellulose