Author/Authors :
WANG, Honggang Dept. of Gastroenterology - Huai’an First People’s Hospital - Nanjing Medical University, Huai’an, P. R. China , WANG, Lizhen Dept. of Medical Center for Digestive Diseases - the Second Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China , XIE, Rui Dept. of Gastroenterology - Huai’an First People’s Hospital - Nanjing Medical University, Huai’an, P. R. China , DAI, Weijie Dept. of Gastroenterology - Huai’an First People’s Hospital - Nanjing Medical University, Huai’an, P. R. China , GAO, Chengcheng Dept. of Gastroenterology - Huai’an First People’s Hospital - Nanjing Medical University, Huai’an, P. R. China , SHEN, Peng Dept. of Gastroenterology - Huai’an First People’s Hospital - Nanjing Medical University, Huai’an, P. R. China , HUANG, Xiaodan Dept. of Medical Center for Digestive Diseases - the Second Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China , ZHANG, Faming Dept. of Medical Center for Digestive Diseases - the Second Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China , YANG, Xiaozhong Dept. of Gastroenterology - Huai’an First People’s Hospital - Nanjing Medical University, Huai’an, P. R. China , JI, Guozhong Dept. of Medical Center for Digestive Diseases - the Second Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China
Abstract :
Body mass index (BMI) has been demonstrated to be associated with serum uric acid (SUA) level in many developed countries, however, there is still a lack of large sample study in Jiangsu Province, one of the most economically developed regions in China, where fat-rich diet is common.Through retrospective analysis in healthy subjects, we determined the association of BMI with hyperuricemia risk. Data of 39,736 participants from January 2011 to June 2013 in China were analyzed for parameters including physical examinations and biochemical blood analysis.On univariate analysis, SUA was positively correlated with age, SBP, DBP, BMI, FPG, red blood cell count, hemoglobin, white blood cell count, platelet, cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, ALT, AST, bilirubin, albumin, BUN and creatinine. SUA was significantly elevated in a linear fashion as BMI increased, and SUA in obesity was significantly higher than underweight. The prevalence of hyperuricemia remained approximately 2.98 times greater among individuals with overweight, and 5.96 times greater among obesity, compared to individuals with underweight.There is a positive relationship between BMI and SUA among healthy subjects in Jiangsu province, China.
