Author/Authors :
Cai, Damin Department of Immunology - School of Basic Medical Sciences - Lanzhou University, Lanzhou, China , Zhang, Si Department of Pathogenic Biology - School of Basic Medical Sciences - Lanzhou University, Lanzhou, China , Wu, Julong Department of Pathogenic Biology - School of Basic Medical Sciences - Lanzhou University, Lanzhou, China , Wang, Xun Department of Pathogenic Biology - School of Basic Medical Sciences - Lanzhou University, Lanzhou, China , Wang, Meng Department of Pathogenic Biology - School of Basic Medical Sciences - Lanzhou University, Lanzhou, China , Lu, Xiaoling Department of Immunology - School of Basic Medical Sciences - Lanzhou University, Lanzhou, China , Chen, Huiyu Department of Immunology - School of Basic Medical Sciences - Lanzhou University, Lanzhou, China , Wang, Qian Department of Immunology - School of Basic Medical Sciences - Lanzhou University, Lanzhou, China , Ma, Xingming Department of Immunology - School of Basic Medical Sciences - Lanzhou University, Lanzhou, China
Abstract :
Background: Praziquantel, an antischistosomal compound, is used as first-line drug for chemotherapy of Schistosoma japonicum since 1984. In this article, we conducted a systematic review and mete-analysis to evaluate the efficacy and safety of different dosages of praziquantel (PZQ) for treatment of Schistosoma japonicum.
Evidence Acquisition: A number of six articles published in peer-reviewed journals before December 2012 were selected for analysis after searching the following literature databases: PubMed/Medline, the Chinese WanFang Literature Database, China National Knowledge Infrastructure (1994-2012.12), and the Chinese Biomedical Literature (1978-2012.12).
Results: The meta-analyses showed that there is no statistically significant difference of the negative rate on the egg using 40 mg/kg compared to 60 mg/kg PZQ for S. japonicum treatment (RR 0.79, 95% CI 0.46 1.35; P < 0.39). The meta-analysis showed that there is no statistically significant difference of the side effects using 30 mg/kg compared with 40 mg/kg (RR 0.97, 95% CI 0.68 1.38; P = 0.87), 40 mg/kg compared with 60 mg/kg (RR 0.79, 95% CI 0.46 1.35; P = 0.39) and 50 mg/kg compared with 60 mg/kg (RR 0.89, 95% CI 0.56 1.42; P = 0.63).
Conclusions: According to the results, there is no statistically significant difference in different doses of PZQ for treating S. japonicum
