Title of article
Effect of Fas -670 A/G Gene Polymorphism on Corneal Allograft Endothelial Rejection
Author/Authors
Jahadi Hosseini, Hamid Reza Department of Ophthalmology - Poostchi Eye Research Center - Autoimmune Diseases Research Center - Shiraz University of Medical Sciences , Kamali Sarvestani, Eskandar Department of Immunology - , Akbari, Mitra Department of Ophthalmology - Poostchi Eye Research Center - Autoimmune Diseases Research Center - Shiraz University of Medical Sciences , Mosallaei, Mahnaz Department of Ophthalmology - Poostchi Eye Research Center - Autoimmune Diseases Research Center - Shiraz University of Medical Sciences
Pages
5
From page
28
To page
32
Abstract
Background: Human cornea expresses functional Fas-ligand capable of killing Fas+
activated lymphocytes. Fas expression is partly regulated by -670 A/G polymorphism in
the promoter region of Fas gene. Objective: The aim of the present study is to determine the association between Fas-670A/G polymorphism and survival of corneal transplantation. Methods: In 276 graft recipients who mainly underwent penetrating keratoplasty because of keratoconus, bullous keratopathy and corneal opacity, Fas -670 A/G polymorphism was determined by allele specific oligonucleotide polymerase chain reaction (ASO-PCR) techniques. Results: There was no statistically significant relationship between Fas -670 A/G polymorphism and rejection episode (p=0.35). Moreover, the relationship between this polymorphism and rejection episode outcome (transplant recovery vs failure) was not statistically significant (p=0.13). Conclusion: The results of the present study show no significant correlation between corneal graft rejection, rejection recovery and Fas -670A/G gene polymorphism.
Keywords
Corneal Transplantation , Fas Ligand , Rejection
Journal title
Astroparticle Physics
Serial Year
2009
Record number
2420629
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