Title of article :
Peganum harmala seed extract can prevent HSV-1 replication in vitro
Author/Authors :
Kiani, S.J Department of Virology - Iran University of Medical Sciences, Tehran , Shahrabadi M, Shamsi Department of Virology - Iran University of Medical Sciences, Tehran , Ataei, A Department of Virology - Iran University of Medical Sciences, Tehran , Sajjadi, N Department of Virology - Iran University of Medical Sciences, Tehran
Abstract :
Peganum harmala L. (Zygophylaceae) has been used in a variety of practical
applications in medical science. Our objective in the current study was to determine the effects of the seed extract on Herpes simplex virus type 1 (HSV-1) replication in Vero cells. Different concentrations (100, 500, 571, 667, 800 and 1000 μg/ml) of the extract were examined. Experiments were carried out using Vero cells. P.harmala seed extract was found to be non-toxic to Vero cells up to a concentration of 667 μg/ml. The antiviral activity of nontoxic concentration against HSV-1 was tested. The replication of HSV-1 was inhibited, indicating that the P.harmala L. extract contains an anti-HSV-1 substance.
Keywords :
Peganum harmala L , Vero cells , TCID50 , Cytotoxicity
Journal title :
Astroparticle Physics
