Author/Authors :
Nourinia, Ramin Ophthalmic Research Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Montahai, Talieh Ophthalmic Research Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Amoohashemi, Nasim Ophthalmic Research Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Hassanpour, Hossein Ophthalmic Research Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Soheilian, Masoud Ophthalmic Research Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract :
Purpose: To report a case of idiopathic retinal vasculitis, aneurysms and neuroretinitis
(IRVAN) syndrome associated with positive perinuclear antineutrophil cytoplasmic
antibody (P-ANCA).
Case Report: A 51-year-old man presented with loss of vision in his right eye since
many years ago and blurred vision in his left eye over the past year. Ophthalmologic
examination revealed optic atrophy and old vascular sheathing in the right eye and
blurred disc margin, macular exudation, flame shaped hemorrhages, retinal vascular
sheathing and multiple aneurysms at arterial bifurcation sites in the left eye, findings
compatible with IRVAN syndrome. On systemic workup, the only notable finding
was P-ANCA positivity.
Conclusion: IRVAN syndrome may be a retinal component of P-ANCA associated
vasculitis.
