Author/Authors :
Amini, Safieh Dept. of Hepatitis and AIDS - Pasteur Institute of Iran, Tehran , Andalibi Mahmoodabadi, Saied Dept. of Hepatitis and AIDS - Pasteur Institute of Iran, Tehran , Taghavinejad, Faramarz Dept. of Hepatitis and AIDS - Pasteur Institute of Iran, Tehran , Joulaie, Mahsa Dept. of Hepatitis and AIDS - Pasteur Institute of Iran, Tehran , Mahmoodi Farahani, Mahmoud Dept. of Epidemiology & Biostatistics - School of Public Health - Tehran Medical Sciences , Hekmat, Soheila Dept. of Hepatitis and AIDS - Pasteur Institute of Iran, Tehran
Abstract :
Mother to child transmission of Hepatitis B Virus is considered as the major route of HBV infection in newborns in Asia. But there is not enough data available on percentage of HBV transplacental transmission in Iran. 1219 pregnant women of Mazandaran province were screened for HBV markers (HBsAg, anti-HBc and anti-HBs). The infants born to HBV positive mothers were tested for the same markers by enzyme-linked immunosorbent assay. Presence of HBV-DNA in HBsAg and anti-HBc positive mothers and cord blood of their babies were also tested by PCR technique. HBsAg was detected in 2.6% of mothers, but only 20 %( 5/25) of neonates cord blood of carrier mothers were HBsAg positive. Hepatitis BeAg was detected in 12 % 3/25) of carriers mothers and in cord blood of their babies. HBV-DNA was detected in 12 % 3/25) of carrier mothers but none of the babies' were positive for it. Meanwhile, HBV-DNA was detected in 6.5 % 5/76) of HBsAg negative mothers who were anti-HBc positive. Despite presence of 2.6% carrier mothers in Mazandaran province, maternal transmission of HBV dose not seem to be the main route of infection.
Keywords :
Transplacental , Mother , Cord blood , HBV , Iran
