Title of article :
In vitro Analysis of Antioxidant, Antimicrobial and Antiproliferative Activity of Enteromorpha antenna, Enteromorpha linza and Gracilaria corticata Extracts
Author/Authors :
Narasimhan, Manoj Kumar Department of Genetic Engineering - School of Bio-engineering - SRM University, Kattankulathur, India , Pavithra, Shenoy K Department of Genetic Engineering - School of Bio-engineering - SRM University, Kattankulathur, India , Krishnan, Vishnupriya Department of Genetic Engineering - School of Bio-engineering - SRM University, Kattankulathur, India , Chandrasekaran, Muthukumaran Department of Industrial Biotechnology - Government College of Technology, Coimbatore, India
Pages :
9
From page :
151
To page :
159
Abstract :
Background: Seaweeds are taxonomically diverse benthic algae, which are rich in bioactive compounds. These compounds have a potential application in medicine. Objectives: The aim of the study was to investigate the bioactive properties of three seaweed samples, Enteromorpha antenna, Enteromorpha linza and Gracilaria corticata were collected from the shoreline of Mahabalipuram, Tamilnadu. Materials and Methods: Bioactive components were extracted by using various solvents. Antioxidant analysis methods like scavenging activity of nitric oxide, hydrogen peroxide, hydroxyl radicals, free radical scavenging (DPPH), FRAP (ferric reducing ability plasma) ability and reducing power were carried out. MTT assay was employed to study the anticancer activity against cancer cell lines Hep-G2, MCF7 and normal VERO cell lines. Results: It was found that methanolic extracts elicited higher total phenolic content, higher percentage scavenging activity of nitric oxide, hydrogen peroxide, hydroxyl radicals, free radical scavenging (DPPH), FRAP (ferric reducing ability plasma) ability and reducing power. Different concentrations of crude methanolic extracts of seaweeds showed potential antimicrobial activity by well diffusion method. Crude methanolic extract of G. corticata had significant anticancer activity followed by E. antenna and E. linza on cancer cell lines Hep-G2, MCF7 and normal VERO cell lines by MTT assay. Conclusions: The methanolic extracts of seaweeds Enteromorpha antenna, Enteromorpha linza and Gracilaria corticata possess high total phenolic content and shows a good free radical scavenging activity and hence are proven to have better antioxidant activity and they might be good candidates for further investigations in order to develop potential anticancer drugs
Keywords :
Antioxidants , Reactive Oxygen Species , Seaweed
Journal title :
Astroparticle Physics
Serial Year :
2013
Record number :
2421368
Link To Document :
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