Author/Authors :
PATEL, P. N. Department of Pharmacology - College of Veterinary Science - Anand Agricultural University, Anand, India , PATEL, U. D. Department of Pharmacology - College of Veterinary Science - Anand Agricultural University, Anand, India , BHAVSAR, SH. K. Department of Pharmacology - College of Veterinary Science - Anand Agricultural University, Anand, India , THAKER, A. M. Department of Pharmacology - College of Veterinary Science - Anand Agricultural University, Anand, India
Abstract :
Pharmacokinetics of cefepime was studied following single dose intravenous and intramuscular
administration at the dose of 20 mg/kg of body weight in sheep. Drug concentration in serum was
determined using high performance liquid chromatography (HPLC). Following single dose intravenous
administration, the drug was rapidly distributed (t1/2α: 0.20 ± 0.02 h) and eliminated (t1/2β: 2.54 ± 0.12 h)
from the body. The area under curve (AUC0-∞) was 135.50 ± 5.63 μg h/mL. The drug was cleared at the
rate of 2.48 ± 0.09 mL/min/kg with mean residence time (MRT) of 2.84 ± 0.13 h. Following IM
administration, the drug was rapidly absorbed (Cmax: 26.34 ± 1.44 μg/mL; tmax: 0.75 h) and slowly
eliminated (t1/2β: 5.17 ± 0.44 h) from body. The volume of distribution at steady state (Vdss), area under
curve (AUC), total body clearance (ClB) and mean residence time (MRT) were 1.11 ± 0.10 L/kg, 140.90 ±
8.67 μg h/mL, 0.15 ± 0.01 mL/min/kg and 6.89 ± 1.0 h, respectively. The bioavailability of cefepime
following intramuscular administration was 103 ± 8.0 %.
Keywords :
Pharmacokinetics , Cefepime , Sheep , Intravenous , Intramuscular
