Title of article
Anti-Inflammatory Effect of Oleuropein in Experimental Rat Spinal Cord Trauma
Author/Authors
Khalatbary, AR Department of Anatomy - Faculty of Medicine - Mazandaran University of Medical Sciences, Khazar Boulevard, Sari, Iran , Zarrinjoei, GhR Razi Herbal Medicines Research Center - Lorestan University of Medical Sciences, Khorramabad, Iran
Pages
6
From page
229
To page
234
Abstract
Background: Spinal cord injury stimulates an inflammatory reaction that causes substantial secondary damage
inside the injured spinal tissue. The purpose of this study was to determine the anti-inflammatory effect of oleuropein
on traumatized spinal cord.
Methods: Rats were randomly divided into four groups of 7 rats each as follows: Sham-operated group, trauma
group, and oleuropein treatment groups (20 mg/kg, ip, immediately and 1 hour after spinal cord injury). Spinal
cord samples were taken 24 hours after injury and studied for immunohistochemistry of tumor necrosis factor-α
(TNF-α), interleukin-1β (IL-1β), nitrotyrosine, inducible nitric-oxide synthase (iNOS), cyclooxygenase-2 (COX-2),
and poly(ADP-ribose) polymerase (PARP).
Results: Attenuated TNF-α, IL-1β, nitrotyrosine, iNOS, COX-2, and PARP expression could be detected in the
oleuropein-treated rats.
Conclusion: Oleuropein modulates inflammatory reactions following spinal cord injury.
Keywords
Oleuropein , Spinal cord , Trauma , Inflammation , Rat
Journal title
Astroparticle Physics
Serial Year
2012
Record number
2422006
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