Author/Authors :
Khazdair, Mohammad Reza Department of Physiology - School of Medicine and pharmaceutical Research Center - Mashhad University of Medical Sciences., Mashhad, IR Iran , Boskabady, Mohammad Hossein Department of Physiology - School of Medicine and pharmaceutical Research Center - Mashhad University of Medical Sciences., Mashhad, IR Iran , Afshari, Reza Department of Toxicology - School of Medicine - Mashhad University of Medical Sciences,, Mashhad, IR Iran , Dadpour, Bita Department of Toxicology - School of Medicine - Mashhad University of Medical Sciences,, Mashhad, IR Iran , Behforouz, Amir Department of Physiology - School of Medicine and pharmaceutical Research Center - Mashhad University of Medical Sciences., Mashhad, IR Iran , Javidi, Mohammad Department of Physiology - School of Medicine and pharmaceutical Research Center - Mashhad University of Medical Sciences., Mashhad, IR Iran , Abbasnezhad, Abbasali Department of Physiology - School of Medicine and pharmaceutical Research Center - Mashhad University of Medical Sciences., Mashhad, IR Iran , Moradi, Valiallah Toxicology Laboratory - Imam Reza Hospital, Mashhad, IR Iran , Tabatabaie, Saleh Iranian Red Crescent Hospital, Dubai, UAE
Abstract :
Background: The exposure to noxious agwents such as lead my cause lung disorders. Objectives: In the present study, pulmonary function tests and self-reported respiratory symptoms in lead exposure workers were compared
with matched control subjects. Materials and Methods: The frequency of respiratory symptoms were evaluated in a sample of 108 lead exposure workers and 100 control
subjects with similar age using a questionnaire including questions on respiratory symptoms in the past year. Pulmonary function tests (PFT)
were also measured in lead exposure workers and in controls. Results: Most lead exposure workers (63%) reported work-related respiratory symptoms. Chest tightness (26%), cough (17%) and sputum (16%)
were the most common symptoms and only 6% of lead exposure workers reported wheezing (P < 0.001 for all case except wheezing). Most PFT
values were also significantly reduced among lead exposure workers (P < 0.05 to P < 0.001 except MEF75, MEF50, MEF25, and MMEF. The lead
concentration in urine and serum of lead exposure workers were significantly higher than control (P < 0.001 for both cases). Conclusions: These results showed that c lead exposure workers have higher frequencies of respiratory symptoms higher serum and urine
lead concentration but lower PFT values.
Keywords :
Lead , Signs and Symptoms , Respiratory , Respiratory Function Tests
