Author/Authors :
Movahedi, Masoud Department of Allergy and Clinical Immunology - Children's Medical Center Tehran University of Medical Sciences , Tavakol, Marzieh Department of Allergy and Clinical Immunology - Shahid Bahonar Hospital Alborz University of Medical Sciences , Hirbod-Mobarakeh, Armin Molecular Immunology Research Center, Department of Immunology - School of Medicine Tehran University of Medical Sciences, Students’ Scientific Research Center - Tehran University of Medical Sciences , Gharagozlou, Mohammad Department of Allergy and Clinical Immunology - Children's Medical Center Tehran University of Medical Sciences , Aghamohammadi, Asghar Department of Allergy and Clinical Immunology - Children's Medical Center Tehran University of Medical Sciences, Research Center for Immunodeficiencies, Children’s Medical Center, Pediatrics Center of Excellence - Tehran University of Medical Sciences , Tavakol, Zahra Student’ Research Committee - Kermanshah University of Medical Sciences , Momenzadeh, Kaveh Students’ Scientific Research Center - Tehran University of Medical Sciences , Nabavi, Mohammad Department of Allergy and Immunology - Rasool-e-Akram Hospital, Iran University of Medical Sciences , Dabbaghzade, Abbas Department of Allergy and Clinical Immunology - Children's Medical Center Tehran University of Medical Sciences , Mosallanejad, Asieh Imam Hosein Medical Center - Shahid Beheshti University of Medical Sciences , Rezaei, Nima Molecular Immunology Research Center, Department of Immunology - School of Medicine Tehran University of Medical Sciences, Research Center for Immunodeficiencies, Children’s Medical Center, Pediatrics Center of Excellence - Tehran University of Medical Sciences
Abstract :
Chronic urticaria is the most common skin disease, characterized by chronic cutaneous lesions which severely debilitates patients in several aspects of their everyday life. Vitamin D is known to exert several actions in the immune system and to influence function and differentiation of mast cells, central role players in the pathogenesis of chronic idiopathic urticaria. This study was performed to evaluate the relationship between vitamin D levels and susceptibility to chronic idiopathic urticaria. One hundred and fourteen patients with chronic idiopathic urticaria were recruited in this study along with one hundred and eighty seven sex-matched and age-matched healthy volunteers as the control group. For each patient, urticaria activity score was calculated and autologous serum skin test was done. Vitamin D metabolic statue was measured in serum as 25 hydroxyvitamin D using enzyme immunoassay method. Patients with chronic idiopathic urticaria significantly showed lower levels of vitamin D. Vitamin D deficiency was significantly associated with increased susceptibility to chronic idiopathic urticaria. There was a significant positive correlation between vitamin D levels and urticaria activity score. This study showed that patients with chronic idiopathic urticaria had reduced levels of vitamin D, while vitamin D deficiency could increase susceptibility to chronic idiopathic urticaria.
Keywords :
Cholecalciferol , Mast cells , Urticaria , Vitamin D , Vitamin D deficiency
