Title of article
First report of OXA-143-lactamase producing Acinetobacter baumannii in Qom, Iran
Author/Authors
Sarikhani, Zohreh Department of Microbiology - Qom Branch - Islamic Azad University, Qom , Nazari, Razieh Department of Microbiology - Qom Branch - Islamic Azad University, Qom , Nateghi Rostami, Mahmoud Center for Research and Training in Skin Diseases and Leprosy - Tehran University of Medical Sciences
Pages
5
From page
1282
To page
1286
Abstract
Objective(s): Antibiotic resistance in Acinetobacter baumannii and outbreaks caused by this organism have been reported from several areas of the world. The present study aimed at determining the antibiotic susceptibility profiles and the distribution of OXA-type beta-lactamases among Iranian Acinetobacter baumannii isolates from Qom of Iran. Materials and Methods: For this study, 108 non-duplicate A. baumannii isolates were obtained from clinical specimens in four teaching hospitals in Qom in the central of Iran. The antimicrobial susceptibility of isolates was tested by standard disk diffusion and prevalence of bla OXA genes was investigated by PCR method.
Results: Among 97 carbapenem non-susceptible isolates of A. baumannii, 90.72% (88 isolates) isolates showed extensive drug resistance to multiple antibiotics. Among carbapenem resistant isolates, 100% carried blaOXA-51-like, 82.47% carried blaOXA-23-like, 55.67% carried blaOXA-58-like, 22.68% carried blaOXA-40-like and 14.43% had blaOXA-143-like resistance genes. Conclusion: This study demonstrated high genetic diversity of OXA genes among isolates of A. baumannii in Qom, Iran.
Keywords
Acinetobacter baumannii , blaOXA-143 , Carbapenem resistance , Iran , Polymerase chain reaction
Journal title
Astroparticle Physics
Serial Year
2017
Record number
2423956
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