Author/Authors :
Omidi, Salma Department of Endodontics - Dental School, Mazandaran University of Medical Sciences, Sari , Javidi, Maryam Dental Material Research Center - Department of Endodontics - Dental School, Mashhad University of Medical Sciences, Mashhad , Zarei, Mina Dental Material Research Center - Department of Endodontics - Dental School, Mashhad University of Medical Sciences, Mashhad , Mushakhian, Siavash Dental Material Research Center - Department of Endodontics - Dental School, Mashhad University of Medical Sciences, Mashhad , Jafarian, Amirhossein Department of Pathology - Ghaem Hospital, University of Medical Sciences, Mashhad
Abstract :
Introduction: The aim of this animal study was to evaluate the histological response of the
new nano zinc-oxide eugenol (NZOE) sealer in comparison with Pulp Canal Sealer (ZOE
based) and AH-26 (epoxy resin sealer). Methods and Materials: A total of 27 Wistar rats
were used. Four polyethylene tubes were implanted in the back of each rat (three tubes
containing the test materials and an empty tube as a control). Then, 9 animals were sacrificed
at each interval of 15, 30 and 60 days, and the implants were removed with the surrounding
tissues.Samples were evaluated for the presence of inflammatory cell (mononuclear cell),
vascular changes, fibrous tissue formation and present of giant cell. Comparisons between
groups and time-periods were performed using the Kruskal-Wallis and Mann-Whitney U
non-parametric tests. The level of significance was set at 0.05. Results: No significant
difference was observed in tissue reactions and biocompatibility pattern of three sealers
during 3 experimental periods (P<0.05). In all groups the tissue behavior showed tendency to
decrease the irritation effect over time. Conclusion: The new nano zinc-oxide eugenol sealer
has histocompatibility properties comparable to conventional commercial sealers.
Keywords :
Biocompatibility , Nanoparticle , Tissue Reaction , Zinc-Oxide Eugenol
