Sarcopenia Is Associated with Cognitive Impairment and Depression in Elderly Korean Women

Background: Sarcopenia has been implicated in the increased risk for cognitive impairment and depression associated with aging. In this cross-sectional study, we investigated the relationship of sarcopenia with cogni-tive impairment (MCI) and depression in a sample of 201 community-dwelling Korean women (mean age of 74.0±6.8 yr) between 2014 and 2015. Methods: The Korean version of mini-mental state examination and the center for epidemiologic studies de-pression scale was used to assess cognitive performance and depression, respectively. Grp strength was meas-ured with a dynamometer. Demographics, body composition, education, alcohol consumption, and history of cardiovascular diseases were assessed as covariates. Results: Odds ratio (OR) and 95% confidence interval (95% CI) of MCI and depression were calculated ac-cording to sarcopenia status. Compared to non-sarcopenic, pre-sarcopenic and sarcopenic women had the ORs of 2.160 (95% CI of 0.840 - 5.554, P=0.030) and of 5.493 (95% CI of 1.854 - 16.270, P=0.002) for MCI. The or of pre-sarcopenia for MCI remained significant (P=0.030) even after adjustments for age, body mass index (BMI), lean body mass, and education, while the or of sarcopenia for MCI was no longer significant (P=0.084) when adjusted for the covariates. Compared to non-sarcopenic, pre-sarcopenic and sarcopenic women had the ORs of 3.750 (95% CI of 1.137 - 12.370, P=0.030) and of 4.687 (95% CI of 1.127 -19.505, P=0.034) for depression. The ORs of pre-sarcopenia and sarcopenia for depression remained statistically sig-nificant (P=0.020 and P=0.042, respectively) even after adjusted for the covariates Conclusion: Sarcopenia was significantly associated with MCI and depression in otherwise healthy community dwelling elderly Korean women.