Association of IL-8 (-251 A/T) Gene Polymorphism with Clinical Parameters and Chronic Periodontitis

Objective: To investigate the correlation between IL-8 (-251 A/T) gene polymor- phism and susceptibility to chronic periodontitis as well as different clinical para- meters and severity of the condition in patients referred to dental school, Shiraz University of Medical Sciences, Shiraz, Iran. Materials and Methods: In this randomized cross sectional study, 227 non- smoking patients with chronic periodontitis (test) and 40 healthy individuals (con- trol) were enrolled in this experiment and the following clinical parameters were employed in the study: Periodontal Pocket Depth (PPD), Clinical Attachment Level (CAL) and Bone Loss (BL). All participants underwent the PCR (Polyme- rase Chain Reaction) test to detect 251 A/T Single Nucleotide Polymorphism of IL8 gene. Results: No significant correlation was perceived between different genotypes of IL-8 and the severity of the periodontal condition (P= 0.164), neither did we detect any substantial association between different IL-8 genotypes and the mean PPD (P=0.525), CAL (P=0.151), BL (P=0.255), PI (P=0.087), BOP (P=0.265) and the average number of teeth (P=0.931). Conclusion: The results implied that there was no explicit correlation between 251 (A/T) IL-8 gene polymorphism and the severity of the chronic periodontal disease or to the susceptibility to it