Author/Authors :
Fabian, Unyime Aniekpon Department of Chemical Pathology - College of Medicine - University of Ibadan, Ibadan, Nigeria , Charles Davies, Mabel Ayebatonyo Department of Chemical Pathology - College of Medicine - University of Ibadan, Ibadan, Nigeria , Fasanmade, Adesoji Adedipe Department of Medicine - College of Medicine - University of Ibadan, Ibadan, Nigeria , Olaniyi, John Ayodele Department of Haematology - College of Medicine - University of Ibadan, Ibadan, Nigeria , Oyewole, Oyediran Emmanuel Department of Health Promotion and Education - College of Medicine, University of Ibadan, Ibadan, Nigeria , Owolabi, Mayowa Ojo Department of Medicine - College of Medicine - University of Ibadan, Ibadan, Nigeria , Adebusuyi, Jane Roli Medical Social Services Department - University College Hospital, Ibadan, Nigeria , Hassan, Olufunke Olayemi Medical Social Services Department - University College Hospital, Ibadan, Nigeria , Ajobo, Babatunde Mohammed Dietetics Department - University College Hospital, Ibadan, Nigeria , Ebesunun, Maria Onomhaguan Department of Chemical Pathology - College of Health Sciences - Olabisi Onabanjo University, Ago-Iwoye, Nigeria , Adigun, Kehinde General Out Patient Unit - University College Hospital, Ibadan, Nigeria , Akinlade, Kehinde Sola Department of Chemical Pathology - College of Medicine - University of Ibadan, Ibadan, Nigeria , Arinola, Olatubosun Ganiyu Department of Chemical Pathology - College of Medicine - University of Ibadan, Ibadan, Nigeria , Agbedana, Emmanuel Oluyemi Department of Chemical Pathology - College of Medicine - University of Ibadan, Ibadan, Nigeria
Abstract :
Background: Pituitary and gonadal dysfunctions resulting from increased adiposity
leading to disturbances of sexual and reproductive functions have been reported in
males with metabolic syndrome (MS) and type 2 diabetes mellitus (DM2). The aim
of this study was to evaluate sexual dysfunction, leptin, and reproductive hormones
in Nigerian males with MS and DM2.
Methods: Participants were 104 men (34 males with DM2, 17 men with MS and 53
men with normal body mass index (18.5-24.9 Kg/m2) without MS (controls)). The
International Diabetes Federation (2005) criteria were used for MS diagnosis. Reproductive
history, anthropometry, blood pressure (BP) and 10 ml fasting blood
samples were obtained by standard methods. Fasting plasma glucose, total cholesterol,
triglycerides and high density lipoprotein cholesterol were determined by enzymatic
methods while low density lipoprotein cholesterol was calculated. Leptin,
follicle stimulating hormone (FSH), luteinising hormone (LH), prolactin, testosterone
and oestrogen were determined by enzyme immunoassay (leptin by Diagnostic
Automation, Inc.; others by Immunometrics (UK) Ltd.) while oestrogen-testosterone
ratio was calculated. Data analyzed using ANOVA, Chi square and multiple regression
were statistically significant at p<0.05.
Results: Testosterone was significantly lower in MS than controls while oestradiol
and ETR were significantly higher in MS compared with controls and DM2 group
(p<0.05). ETR significantly predicted testosterone in all groups (p<0.05). Significantly
lower libido was observed in men in MS than controls and DM2 groups
(p<0.05).
Conclusion: Sexual and reproductive dysfunction may be related to increased conversion
of testosterone to oestrogen in increased adipose mass in men with metabolic syndrome and type 2 diabetes mellitus.
Keywords :
Cardiovascular disease , Pituitary hormones , Sex hormone , Sexual dysfunction , Type 2 diabetes mellitus , Leptin , Metabolic syndrome , Lipids
