Author/Authors :
Gilany, Kambiz Reproductive Biotechnology Research Center - Avicenna Research Institute, ACECR, Tehran, Iran , Minai Tehrani, Arash Nanobiotechnology Research Center - Avicenna Research Institute, ACECR, Tehran, Iran , Amini, Mehdi Reproductive Biotechnology Research Center - Avicenna Research Institute, ACECR, Tehran, Iran , Agharezaee, Niloofar Reproductive Biotechnology Research Center - Avicenna Research Institute, ACECR, Tehran, Iran , Arjmand, Babak Metabolomics and Genomics Research Center - Endocrinology and Metabolism Molecular Cellular Sciences Institute - Tehran University of Medical Sciences, Tehran, Iran
Abstract :
Currently, there are 20,197 human protein-coding genes in the most expertly curated
database (UniProtKB/Swiss-Pro). Big efforts have been made by the international
consortium, the Chromosome-Centric Human Proteome Project (C-HPP) and independent
researchers, to map human proteome. In brief, anno 2017 the human proteome
was outlined. The male factor contributes to 50% of infertility in couples. However,
there are limited human spermatozoa proteomic studies. Firstly, the development
of the mapping of the human spermatozoa was analyzed. The human spermatozoa
have been used as a model for missing proteins. It has been shown that human
spermatozoa are excellent sources for finding missing proteins. Y chromosome proteome
mapping is led by Iran. However, it seems that it is extremely challenging to
map the human spermatozoa Y chromosome proteins based on current mass spectrometry-
based proteomics technology. Post-translation modifications (PTMs) of
human spermatozoa proteome are the most unexplored area and currently the exact
role of PTMs in male infertility is unknown. Additionally, the clinical human spermatozoa proteomic analysis, anno 2017 was done in this study.
Keywords :
Human , Proteome , Proteomics , Spermatozoa , Y chromosome
