In silico Biological Activity of Steroids from the Marine Gastropods Telescopium telescopium Collected from South West Coast of India

Background: The purpose of this study was to investigate the sterol profiling and pre-dict the pharmacological potential of marine gastropod Telescopium telescopium (T. telescopium), collected from mangrove ecosystem in the South west coast of India. Methods: Sterol fractions were separated from the crude lipids using 15% ethyl ace-tate. Ethyl acetate fractions were dried under ultrahigh purity N2 and analyzed using GC-MS. The biological activity was predicted using the software CLC-Pred; In silico predictions of cytotoxicity for tumor and non-tumor cell lines and PASS. Results: This study proved the existence of four sterols, of which cholesterol was abun-dant. It was found that most of the steroids profiled from T. telescopium displayed ac-tivity against reproductive system as well as skin related diseases. Conclusion: The predicted anti infertility and skin related activity of the steroids iden-tified from the marine gastropod T. telescopium is useful to attract industrial interest towards this species which will be helpful in rising new combinations with added therapeutic and nutritional worth.