Author/Authors :
Rigi, Sara Department of Anatomy, School of Medicine - Iran University of Medical Science, Tehran, Iran , Sakhaei, Abolhassan Department of Anatomy, School of Medicine - Iran University of Medical Science, Tehran, Iran , Asl, Azadeh Niknam Department of Tissue Engineering - Tehran University of Medical Science, Tehran, Iran , Alizadeh, Akram Department of Tissue Engineering - Tehran University of Medical Science, Tehran, Iran , Beigi, Fatemeh Department of Anatomy, School of Medicine - Iran University of Medical Science, Tehran, Iran , Mehdizadeh, Mehdy Department of Anatomy, School of Medicine - Iran University of Medical Science, Tehran, Iran , Soleimani, Mansooreh Cellular and Molecular Research Center - Department of Anatomy - School of Medicine - Tehran University of Medical Science, Tehran, Iran , Katebi, Majid Stem Cell Research Center - Department of Anatomy - School of Medicine - Hormozgan University of Medical Science, Bandar Abbas, Iran
Abstract :
Coenzyme Q10 is a promising agent for neuroprotection in neurodegenerative diseases. Neuroprotective effects of Coenzyme Q10 demonstrated in some neurodegenerative diseases such as Parkinson, Alzimer and etc. Hippocampus is home of those diseases. We assayed Coenzyme Q10 effects on Hippocampal injury model and our hypothesis is that Coenzyme Q10 has Neuroprotective effects in some neurodegenerative diseases via hippocampus. For this purpose 24 Balb/c mouse took in 4 groups: Control (Without any treatment), Vehicle (Treated with sesame oil as Coenzyme Q10 vehicle), Hyppocampal injury model (Treated with Trimethyltin chloride neurotoxin, 2.5 mg per kg IP), and test (Treated with Coenzyme Q10 after
Trimethyltin chloride injection, 10 mg per kg IP for 2 weeks). After 2 weeks brain harvested and hippocampus tissue assayed by Nissl and Tunnel staining. Hystological
study showed significantly increase of normal cells and decrease of apoptotic cells in test group after Coenzyme Q10 treatment in hippocampus. This study showed Coenzyme Q10 has protective effects in hippocampus after injury and it seems that Neuroprotective effects of Coenzyme Q10 in some neurodegenerative diseases com from that.
