Title of article
Mechanisms and Performances of Adjuvants in Vaccine Immunogenicity
Author/Authors
Gheibihayat, Mohammad Young Researchers and Elite Club - Andimeshk Branch, Islamic Azad University, Andimeshk, Iran , Sadeghinia, Azam Department of Cardiology - Faculty of Medicine - Dezful University of Medical Sciences, Dezful, Iran , Nazarian, Shahram Department of Biology - Faculty of Science - Imam-Hossein University, Tehran, Iran , Adeli, Zahra Department of Microbiology - Islamic Azad University - Damghan Branch, Damghan, Iran
Pages
8
From page
257
To page
264
Abstract
An adjuvant is a substance that is added to a vaccine to increase the body's immune response to the vaccine. Vaccines containing adjuvants are tested for safety in clinical trials before they are licensed for use. The basic action of adjuvants is
stimulating adaptive immune responses. Adjuvants recently licensed for human utilization involve alum squalane oil or water emulsion, influenza virosomes, and few cytokines as IFN-γ and IL-2. Some adjuvants are currently under investigation such as DNA motifs, monophosphoryl lipid A, Cholera Toxin, E. coli heat Labile Toxin, Saponins, Immunostimulating complexes, liposomes, Flt3 ligand as a pleotropic glycoprotein, non-ionic block copolymers. This paper is an overview of most commonly used adjuvants, adjuvant mechanisms, adjuvant formulations and adjuvant limitations.
Keywords
Adjuvants , Vaccine , Immunostimulating Complexe , Alum , MHC
Journal title
Astroparticle Physics
Serial Year
2015
Record number
2427258
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