Author/Authors :
Iman, Maryam Chemical Injuries Research Center - Baqiyatallah University of Medical Sciences, Tehran, Iran , Dashtestani, Fariba Institute of Biochemistry & Biophysics - University of Tehran, Iran , Zafari, Zahra Department of Energy Engineering and Physics - Faculty of Physics - Amirkabir University of Technology , Kamali, Mehdi Nanobiotechnology Research Center - Baqiyatallah University of Medical Science, Tehran, Iran , Ramezani, Manizheh Nanobiotechnology Research Center - Baqiyatallah University of Medical Science, Tehran, Iran , Eskandari, Khadijeh Nanobiotechnology Research Center - Baqiyatallah University of Medical Science, Tehran, Iran
Abstract :
Graphene modified glassy carbon electrodes have been developed for the determi-nation of calcium dobesilate in pharmaceutical formulations. The prepared gra-phene and CNTs were used as a conductive substrate for electrochemical study of calcium dobesilate. The direct electrochemistry of calcium dobesilate showed a reversible cyclic voltammogram with a formal potential of 133 mV (vs. Ag/AgCl) for graphene modified electrodes in 0.1 M phosphate buffer. The linear concentra-tion range of the sensor is 30-120 ng/mL for graphene modified electrode, respec-tively. The lifetime of biosensor is more than 2 weeks. The proposed modified electrode provides a new promising and alternative way to detect calcium dobesi-late.
Keywords :
Graphene , Sensor , Direct Electrochemistry , Calcium Dobesilate
