Title of article :
Critical Roles of Non-coding RNAs in Acute Lymphoblastic Leukemia
Author/Authors :
Mazloumi Gavgani, Maryam Department of Molecular Genetics - Ahar Branch Islamic Azad University, Ahar, Iran , Nargesian, Mansooreh Young Researchers and Elite Club - Ahar Branch Islamic Azad University, Ahar, Iran , Ghorbian, Saeid Department of Molecular Genetics - Ahar Branch Islamic Azad University, Ahar, Iran
Abstract :
MicroRNA (miRNA) is one of the non-codingRNA(ncRNA) molecules with 21 - 25-nucleotide length, playing an important role in gene
control by transcriptional gene regulation, chromatin remodeling, genetic imprinting, and translation initiation. The deregulation
of ncRNA can lead to several hematopoietic malignancies such as acute lymphoblastic leukemia (ALL). The study aimed to drawthe
crucial features of miRNA in the pathogenesis of ALL. The findings showed that miRNA expression changes in ALL are typical and involve
several signaling pathways. The variations in miRNA gene expression can lead to the incomplete expression of oncoprotein or
tumor suppressor gene (TSG). It seems that ncRNAs play pivotal roles in the ALL pathogenesis. However, ncRNAs might be interested
as potential diagnostic and prognostic biomarkers in ALL.
Keywords :
Acute Lymphoblastic Leukemia , ALL , miRNA , ncRNA
Journal title :
Astroparticle Physics
