The Catechol-Methyltransferase rs4680 G>A Polymorphism is Associated with Uterine Leiomyoma Susceptibility

Background: Uterine leiomyoma (ULM) is one of the most common medical conditions where the molecular pathogenesis in women in still unknown. Objectives: The aim of the present investigation was to demonstrate the association between catechol-methyltransferase (COMT) (rs4680 G>A) gene polymorphism with the risk of ULM. Methods: In the present case-control study we included 200 peripheral blood samples of women, which consisted of 100 women with ULM and 100 women who were healthy. The genotype frequencies were assessed using polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP) method. Results: The genotype frequencies of COMT (rs4680) gene polymorphism AA + GG vs. GA revealed a significant association with the risk of ULM (OR = 2.453; CI = 1.274 - 4.723, P = 0.006). Conclusions: The findings suggested that the COMT (rs4680) gene polymorphism may be contributed as a predisposing risk factor to ULM.