The Effect of 12‑Week of Aerobic Training on Homocysteine, Lipoprotein A and Lipid Profile Levels in Sedentary Middle‑aged Men

Background: The purpose of this study was to investigate the effect of 12‑week of aerobic training on homocysteine, lipoprotein A and lipid profile levels in sedentary middle‑age men. Methods: This was a quasi‑experimental study. Subjects of the study were 24 men (age 40-60) who participated is the study voluntarily and were randomly assigned in aerobic (n = 12) and control (n = 12) groups. The subjects participated in progressive aerobic training on treadmill 3 times a week (20 min/session (60% maximum heart rate) to 60 min (75% maximum heart rate). Homocysteine, lipoprotein A, triglyceride (TG), cholesterol, low‑density lipoprotein (LDL) and high‑density lipoprotein (HDL) were measured before and after 12‑week. Data were analyzed using paired t‑test and independent t‑test statistical methods. Results: Research findings showed a significant decrease in homocysteine (P = 0.002), lipoprotein A (P = 0.003), TG (P = 0.008), cholesterol (P = 0.024) and LDL (P = 0.019), significant increase in HDL (P = 0.017) in posttest compared to pretest. Furthermore, research findings showed that homocysteine (P = 0.005), lipoprotein A (P = 0.001), TG (P = 0.006), cholesterol (P = 0.015), LDL (P = 0.022), and HDL (P = 0.004) levels between the two groups. Conclusions: These findings reveal the 3 sessions/week of aerobic training cause reduction of homocysteine, lipoprotein A, and lipid profile levels in sedentary middle‑aged men and can be recommended for prevention of cardiovascular disease.